Changes in personality are most likely associated with tumors of the:

Changes in personality are most often linked to tumors of the frontal lobe due to the critical role this region plays in higher cognitive functions, emotional regulation, and social behavior. The frontal lobe is responsible for executive functions such as planning, decision-making, and social interaction; therefore, any disruption in this area, whether from a tumor or other pathology, can significantly affect an individual's personality and behavior.

For instance, a tumor in the frontal lobe may lead to impulsivity, changes in emotional responses, or alterations in social behavior, which are all elements of personality. The impact of these changes often becomes evident in various social situations, where the individual's responses may seem inappropriate or disconnected from their previous behavior.

In contrast, other lobes like the temporal lobe are more associated with memory and auditory processing, and lesions there typically affect memory or language comprehension rather than personality. The occipital lobe primarily processes visual information, while the parietal lobe is involved in sensory perception and integration. Alterations in these areas tend not to have the same direct influence on personality changes as those in the frontal lobe.