What condition is associated with PLEDS?

The condition associated with PLEDS, which stands for periodic lateralized epileptiform discharges, is typically acute cerebral infarction. PLEDS are characterized by the presence of sharp waves that are found predominantly in one hemisphere of the brain and are closely associated with focal cortical irritability. This pattern is often seen on EEG recordings in patients who have experienced an ischemic stroke or other types of focal damage, such as those resulting from an acute cerebral infarction.

In cases of acute cerebral infarction, the resultant brain injury can lead to localized areas of electrical dysfunction, which manifest as PLEDS on an EEG. The presence of these discharges is significant as they may indicate ongoing seizure activity or an increased risk of seizures following a stroke.

The other conditions listed may be associated with various EEG findings but do not typically present with PLEDS. For instance, meningitis may show diffuse slowing or generalized discharges, while Creutzfeldt-Jakob Disease (CJD) often presents with periodic sharp wave complexes rather than laterlized discharges. Metabolic diseases can lead to diffuse abnormalities but not specifically to PLEDS. Hence, the correct association of PLEDS with acute cerebral infarction highlights the importance of recognizing these EEG patterns