What is the most common etiology associated with LPDs/PLEDs?

LPDs (Lateralized Periodic Discharges) and PLEDs (Periodic Lateralized Epileptiform Discharges) are both EEG patterns that are often seen in association with specific neurological conditions. The most common etiology associated with these patterns is ischemic stroke. In the context of an ischemic stroke, particularly in the case of middle cerebral artery involvement, there can be a localized area of cerebral injury due to a lack of blood flow, leading to the characteristic periodic discharges. These discharges represent the brain's response to localized neuronal damage.

Ischemic stroke can lead to a disruption of normal electrical activity, which manifests as LPDs or PLEDs on an EEG. These findings can serve as significant indicators to the neurologist or EEG technologist, suggesting that there is an underlying acute injury to the brain, often requiring immediate medical attention.

Understanding the significance of the relationship between ischemic events and LPDs/PLEDs is fundamental for EEG interpretation and clinical correlation, guiding further management and treatment decisions for patients presenting with these EEG patterns.